Current patient- and physician-reported measures of disease severity and clinical response effectively reflect rapid improvements associated with plasma exchange in myasthenia gravis (MG) patients, a study reports. These findings support the use of these MG-specific outcome measures in clinical trials of rapidly effective therapies for MG, such as plasma…
UCB will add the investigational candidate zilucoplan to its therapeutic pipeline for the treatment of people with myasthenia gravis (MG), after announcing it will acquire the therapy’s developer, Ra Pharmaceuticals. Two Phase 3 trials are currently recruiting participants with generalized myasthenia gravis: the RAISE trial (…
The National Institutes of Health (NIH) awarded $7.8 million to researchers at George Washington University to launch a network for improving research, treatment, and education in myasthenia gravis. This will be the first large and organized effort to focus on the disorder, which affects 20 in 100,000…
Ra Pharmaceuticals announced the first patient enrolled in RAISE, the company’s Phase 3 clinical trial assessing the effectiveness of zilucoplan as a therapy for generalized myasthenia gravis (gMG), has started receiving treatment. Zilucoplan, formerly known as RA101495, is an artificial peptide that binds to complement 5…
Treatment with immunosuppressive agents and Mestinon (pyridostigmine) protects against transition from ocular myesthenia gravis (MG) to a generalized form of the disease among patients with anti-acetylcholine receptor (AchR) antibodies, according to new research. Women, current or former smokers, and patients with thymus hyperplasia (enlargement) or…
Next month’s annual conference of the National Organization for Rare Disorders (NORD) in Washington, D.C., couldn’t come at a better time, says Marshall Summar, MD, chairman of NORD’s board of directors. “The pace of discovery in rare diseases has gone from brisk to hypersonic,” Summar told Bionews Services, publisher…
DAS Therapeutics has acquired GTP-004, an investigational oral treatment for myasthenia gravis, from GT Biopharma, the companies announced. GTP-004 will be named DAS-MG from now on, DAS Therapeutics said on its website. The investigational treatment combines a fixed dose of pyridostigmine — an approved therapy for myasthenia gravis-associated muscle…
Physicians should keep in mind that severe exacerbations in patients with myasthenia gravis (MG) might be triggered by the use of gabapentin (sold under the brand name Neurontin, among others), normally used to control seizures, a case report study says. “Uncontrolled recurrent myasthenia gravis exacerbations secondary…
The diabetes drug metformin, which is largely safe and minimally toxic, can be of therapeutical value for myasthenia gravis, according to a study conducted using a mouse model of the disease. The study, “Metformin attenuates autoimmune disease of the neuromotor system in animal models of myasthenia gravis,” was…
Assessing altered eye movements with a technique called electrooculography (EOG) may become a non-invasive method for early diagnosis of myasthenia gravis (MG), according to new research. The study, “Analysis of Electrooculography Signals for the Detection of Myasthenia Gravis,” was published in the journal Clinical Neurophysiology.
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