A small clinical trial found early signs that Cabaletta Bio’s experimental CAR T-cell therapy rese-cel (resecabtagene autoleucel) may safely ease symptoms for adults with generalized myasthenia gravis (gMG). That’s according to data from the U.S.-based Phase 1/2 RESET-MG trial (NCT06359041), in which participants with different types of…
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More than 90% of people with generalized myasthenia gravis (gMG) treated with telitacicept for about a year achieved deep reductions in symptom severity, with more than 40% showing minimal symptoms that had little to no impact on daily life. That’s according to new data from a China-based Phase…
A second round of Descartes-08, Cartesian Therapeutics’ experimental CAR T-cell therapy, may allow some people with generalized myasthenia gravis (gMG) to sustain clinically meaningful symptom reduction, according to data from a clinical trial. James F. Howard Jr., MD, a trial investigator and University of North Carolina School of…
For many people living with rare neuromuscular diseases, the most meaningful part of a recent Chicago gathering was not just the medical updates — it was finding a community that understood their daily struggles. The realization that they were not alone set the tone for MDA Engage: Chicago, a…
Regeneron Pharmaceuticals’ investigational therapy cemdisiran significantly reduced hospitalization rates among people with generalized myasthenia gravis (gMG) in a global clinical trial. The data from the Phase 3 NIMBLE study (NCT05070858) were presented by trial investigator Ali Habib, MD, a neurologist at the University of California, Irvine, at…
A single dose of Kyverna Therapeutics’ experimental CAR T-cell therapy mivocabtagene autoleucel (miv-cel) led to reductions in symptom severity among people with difficult-to-treat generalized myasthenia gravis (gMG) that have been sustained for up to 1.5 years. Importantly, most participants reached a state where their gMG symptoms have…
People living with myasthenia gravis (MG) have more treatment options today than ever before, and emerging approaches like CAR T-cell therapy could soon add another powerful tool, a neurologist told patients and caregivers at a recent educational event. Even with a growing list of therapies, effective care still…
Myasthenia gravis (MG) patients who didn’t have thymus tumors saw reductions in disease severity and medication use two years after undergoing a type of minimally invasive thymectomy (surgery to remove the thymus gland), a study showed. Most of the 33…
An experimental cell therapy designed to selectively eliminate immune cells that produce the most common disease-driving antibodies in myasthenia gravis (MG) showed promise in laboratory and mouse models. The treatment involves engineering immune T-cells to selectively kill B-cells producing self-reactive antibodies (autoantibodies) against the…
Thymectomy — a surgery to remove the thymus gland — can help keep generalized myasthenia gravis (gMG) under control while decreasing the need for immunosuppressive medications in both younger and older patients without a thymus tumor, a study found. “These findings provide some support to the use of…
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