More than a quarter of patients with generalized myasthenia gravis (gMG) spend more than a year waiting for an accurate diagnosis, according to a survey-based study conducted across five European countries. Study findings also suggested that patients who waited more than one year to be diagnosed might have…
Treatment with Soliris (eculizumab) was effective for managing myasthenic crisis in four people with myasthenia gravis (MG) at a center in China, a study reported. “[Soliris] exhibited a tolerable and efficacious profile in treating patients with [myasthenic crisis],” the researchers wrote, adding that “larger sample sizes and longer…
Kyverna Therapeutics’ experimental cell therapy, KYV-101, has been granted regenerative medicine advanced therapy (RMAT) status by the U.S. Food and Drug Administration (FDA) for treating progressive myasthenia gravis (MG). RMAT designation is intended to expedite the development and FDA review of experimental regenerative treatments that treat, modify, reverse,…
By March, Immunovant plans to initiate four or five pivotal clinical trials of its lead therapeutic candidate IMVT-1402 across a range of autoimmune conditions, including myasthenia gravis (MG). Pivotal, or registrational, trials are large-scale studies whose data could support regulatory applications seeking a therapy’s approval. Immunovant announced…
Patients with generalized myasthenia gravis (gMG) with mild pre-surgery muscle weakness had more favorable outcomes after a thymectomy, which involves the surgical removal of the thymus gland, than those with moderate or severe muscle weakness, a study finds. In their study, “Pre-thymectomy disease severity predicts outcome in…
Remegen enrolled the first U.S. patient in a Phase 3 trial testing the safety and efficacy of telitacicept to treat generalized myasthenia gravis (gMG), according to a company press release, This Phase 3 clinical trial (NCT06456580) is a global, multi-center, randomized, double-blind, placebo-controlled study in which…
The anti-malaria drug dihydroartemisinin, known simply as DHA, showed promise in a rat model of myasthenia gravis (MG) as a potential treatment for the autoimmune disease, a new study reports. In addition to alleviating many MG-related symptoms, DHA inhibited pro-inflammatory T-cells while boosting immune-suppressing T-regulatory cells. Treatment with the…
Soliris (eculizumab) effectively eased symptoms and reduced the need for other medications in adults with myasthenia gravis (MG) in a clinical practice setting, according to two-year data from an observational study called ELEVATE. Findings were reported in the study “United States clinical practice experience with eculizumab in…
People with generalized myasthenia gravis (gMG) with many hospital visits before diagnosis or hard-to-manage disease symptoms at the time of diagnosis tend to accrue higher healthcare-related costs after getting diagnosed, a new study reports. The use of certain treatments before diagnosis and in the year after, as well…
Surgical removal of the thymus, called a thymectomy, may significantly ease the neurological symptoms of patients older than 65 who have myasthenia gravis (MG) and a thymus tumor, according to a new study from researchers in Italy. Overall, nearly 90% of older individuals undergoing thymectomy showed a neurological…
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