How to Manage Medical Burnout With Myasthenia Gravis

Phase 1 Trial of MuSK-CAART Therapy Is Recruiting

MuSK-CAART, an investigational cell-based therapy being developed to treat myasthenia gravis (MG) patients with anti-MuSK antibodies, eliminated disease-driving B-cells in a mouse model of the disease, a study showed. The findings, some of which were reported previously at a scientific conference, supported Cabaletta Bio’s request for a…

Health Canada Approves Ultomiris for AChR-positive gMG

Ultomiris (ravulizumab-cwvz) has been approved in Canada to treat adults with generalized myasthenia gravis (gMG) who are positive for antibodies targeting the acetylcholine receptor (AChR), the most common type of MG-causing antibody. The announcement came less than a year after Ultomiris was approved for the condition in the U.S., and…

Risk Factors For Myasthenic Crisis After Thymectomy Identified

Researchers have identified clinical factors that increase the risk of a post-operative myasthenic crisis (POMC) for patients with myasthenia gravis (MG) who have surgery to remove the thymus gland. Among the risk factors listed are more severe MG with respiratory muscle involvement, pre-operative use of a high dose of pyridostigmine…

Tfh Cell Protein Fragments May Be Potential Biomarkers

Adults with myasthenia gravis (MG) have elevated levels of protein fragments released from T follicular helper (Tfh) cells — an immune cell type involved in the development of autoimmune conditions — in their bloodstream, a study reported. According to researchers, these results suggest that molecules associated with Tfh cells…