News

The U.S. Food and Drug Administration (FDA) has granted orphan drug designation to CNP-106, an experimental treatment that Cour Pharmaceuticals is developing to reprogram the immune system in generalized myasthenia gravis (gMG). “Receiving orphan drug designation for CNP-106 is an important development and regulatory milestone for our…

Measuring changes in blood levels of two proteins — neurofilament light chain (NfL) and calprotectin (CLP) — may show how well people with generalized myasthenia gravis (gMG) respond to Ultomiris (ravulizumab) and Vyvgart (efgartigimod). That’s according to a small, real-world study in Germany that found that rising…

Black patients with generalized myasthenia gravis (gMG) face significantly higher risks of exacerbations compared with their white counterparts, according to a retrospective analysis of healthcare insurance claims from a U.S. database. Exacerbations refer to the worsening of existing symptoms or the appearance of new ones. “Interventions aimed at addressing…

A European Medicines Agency (EMA) committee recommended that the agency approve nipocalimab as an add-on treatment for generalized myasthenia gravis (gMG) patients aged 12 and older who have antibodies against acetylcholine receptor (AChR) or muscle-specific kinase (MuSK). The Committee for Medicinal Products for Human Use (CHMP) recommendation comes a…

People who begin experiencing symptoms of generalized myasthenia gravis (gMG) at the age of 65 or older tend to have a more aggressive initial disease course — but a more favorable prognosis over the following two years. That’s according to a new study from Greece that investigated the short-term…

People with refractory myasthenia gravis (MG) who fail to respond to several treatments may be effectively treated with Vyvgart (efgartigimod alfa-fcab), regardless of the type of self-reactive antibodies they carry. That’s according to a systematic review and meta-analysis, which showed that patients treated with Vyvgart saw their symptoms…

Soliris (eculizumab) and Ultomiris (ravulizumab-cwvz) are generally safe and effective for easing symptoms of generalized myasthenia gravis (gMG) when used in everyday clinical practice. That’s according to data from the MG SPOTLIGHT Registry (NCT04202341), which was established to assess the long-term effectiveness of both therapies in…

Treatment with the experimental injection therapy claseprubart (DNTH103) was well tolerated and appeared to ease symptoms of generalized myasthenia gravis (gMG) in a Phase 2 clinical trial involving people with the autoimmune neuromuscular condition. That’s according to top-line data announced by the therapy’s developer Dianthus Therapeutics. The…

An analysis of the Swedish MG registry suggests that adults with myasthenia gravis (MG) have an impaired quality of life, even when they show low disease activity. Muscle weakness affecting the limbs and breathing primarily drove a diminished quality of life. These findings indicate “an unmet medical need that…

A new Phase 3 clinical trial testing Kyverna Therapeutics’ cell therapy candidate KYV-101 in people with myasthenia gravis (MG) — a study the developer says “supports [a] clear and rapid path to [regulatory approval]” — is expected to start enrolling participants before the end of the year, according to…