Vyvgart (efgartigimod) generally is safe and leads to both significant symptom reductions and improvements in function in people with hard-to-treat generalized myasthenia gravis (gMG), according to a real-world, single-center study in the U.S. These results, the researchers say, “[provide] further support for the use of [Vyvgart] in clinical…
Myasthenia gravis (MG) caused by the presence of self-reactive antibodies targeting muscle-specific kinase (MuSK) affects mostly women in Japan, leading to generalized muscle weakness, particularly in the face and neck, a study reports. About half of 50 study patients had refractory MG, meaning they failed to respond to standard…
Treatment with intravenous immunoglobulin (IVIG) during pregnancy may have helped ease symptoms of a fetal disorder in a girl born to a mother with myasthenia gravis (MG), according to a report from Germany. The woman’s firstborn had developed severe FARAD (or fetal acetylcholine receptor antibody-related disorder), which occurs…
Among people with myasthenia gravis (MG) living in Australia, women and seronegative patients — those whose tests fail to show MG-associated antibodies — reported a significantly higher disease toll in an online survey. This toll included a greater range of disease symptoms, earlier disease onset, longer waits…
Kyverna Therapeutics’ investigational cell therapy KYV-101 safely and effectively improved muscle strength and reduced fatigue in a woman with severe, hard-to-treat generalized myasthenia gravis (gMG), according to a case report. The patient was treated based on an individual case evaluation and outside of a clinical trial. “This groundbreaking…
A new under-the-skin injectable formulation of Vyvgart (efgartigimod alfa) has been approved by the European Commission for adults with generalized myasthenia gravis (gMG) who are positive for antibodies targeting the acetylcholine receptor (AChR) — the most common type of MG-causing antibody. This subcutaneous (under-the-skin) formulation now can be…
Spanish-speaking patients living with myasthenia gravis (MG) — and their caregivers, family members, friends, and anyone else seeking to learn more about the rare neuromuscular disease — are invited to join in the next meeting of the Virtual International Spanish MG Support Group, or Miastenia Gravis Grupo de…
The U.S. Food and Drug Administration (FDA) has cleared an investigational new drug (IND) application from Kyverna Therapeutics, giving the company the go-ahead to launch a Phase 2 clinical trial that will test its cell therapy, KYV-101, in people with myasthenia gravis (MG). This is the fifth IND…
The experimental treatment povetacicept (ALPN-303) may be more effective than current available treatments for myasthenia gravis (MG), according to preclinical data from Alpine Immune Sciences, which is developing the therapy. Specifically, povetacicept outperformed Vyvgart (efgartigimod) and off-label rituximab at reducing disease activity in a mouse model of the…
The U.S. Food and Drug Administration (FDA) has given Cabaletta Bio the go-ahead to launch a Phase 1/2 clinical trial testing its cell therapy CABA-201 in people with generalized myasthenia gravis (gMG). The upcoming trial is expected to enroll a dozen adults with gMG — six who are positive…
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