News

Johnson & Johnson has submitted an application to the U.S. Food and Drug Administration (FDA) seeking approval of nipocalimab to treat people with generalized myasthenia gravis (gMG). The application covers gMG patients who are positive for disease-causing antibodies against acetylcholine receptors (AChRs), muscle-specific kinase (MuSK), and low…

Serious breathing difficulties, called acute respiratory distress, was the initial clinical manifestation of myasthenia gravis (MG) in a 41-year-old woman, who was described in a recent case study. The woman went to the emergency room with severe breathing problems, progressive shortness of breath, coughing, and difficulty swallowing. She was…

Taking Rituximab by itself is as effective as combining it with corticosteroids for treating myasthenia gravis (MG) and has the benefit of reducing the proportion of patients who need rescue therapy and use immunosuppressants, a French study finds. According to researchers, “this indicates that avoiding steroids could reduce…

More than half of myasthenia gravis (MG) patients have fatigue, the severity of which is strongly correlated with their history of exacerbations, that is episodes when their disease worsens, and/or crises, along with delays in their diagnosis. That’s according to a nationwide registry study in Germany that found…

The volume of the extraocular muscles controlling eye movements is decreased in Chinese patients with myasthenia gravis (MG), particularly in those with ophthalmoparesis, or limited eye movement, a study found. Long disease duration was also associated with decreased extraocular muscle volume, but only in patients with ophthalmoparesis. A reduction…

Rituximab effectively treated most myasthenia gravis (MG) patients who were positive for antibodies against muscle-specific tyrosine kinase (MuSK), a small study shows. The therapy eased MG symptoms and led to gains in measures of clinical severity. It also enabled patients to reduce or stop taking other medications,…

More than a quarter of patients with generalized myasthenia gravis (gMG) spend more than a year waiting for an accurate diagnosis, according to a survey-based study conducted across five European countries. Study findings also suggested that patients who waited more than one year to be diagnosed might have…

Treatment with Soliris (eculizumab) was effective for managing myasthenic crisis in four people with myasthenia gravis (MG) at a center in China, a study reported. “[Soliris] exhibited a tolerable and efficacious profile in treating patients with [myasthenic crisis],” the researchers wrote, adding that “larger sample sizes and longer…

Kyverna Therapeutics’ experimental cell therapy, KYV-101, has been granted regenerative medicine advanced therapy (RMAT) status by the U.S. Food and Drug Administration (FDA) for treating progressive myasthenia gravis (MG). RMAT designation is intended to expedite the development and FDA review of experimental regenerative treatments that treat, modify, reverse,…

By March, Immunovant plans to initiate four or five pivotal clinical trials of its lead therapeutic candidate IMVT-1402 across a range of autoimmune conditions, including myasthenia gravis (MG). Pivotal, or registrational, trials are large-scale studies whose data could support regulatory applications seeking a therapy’s approval. Immunovant announced…