Surgical removal of the thymus, called a thymectomy, may significantly ease the neurological symptoms of patients older than 65 who have myasthenia gravis (MG) and a thymus tumor, according to a new study from researchers in Italy. Overall, nearly 90% of older individuals undergoing thymectomy showed a neurological…
A set of inflammatory molecules could be useful as biomarkers for identifying and classifying myasthenia gravis (MG), potentially aiding in the diagnosis of the rare neuromuscular disease, according to a new study led by researchers in Sweden. Proteins and regulatory molecules associated with inflammatory processes could serve as disease…
Intravenous (into-the-vein) treatment with Argenx’s Vyvgart (efgartigimod alfa) resolved a myasthenic crisis — a life-threatening complication of myasthenia gravis (MG) marked by severe breathing problems — in a 57-year-old man who had failed to respond to prior treatments, according to a case study. The findings…
A recent study has reported a potential connection between cancer development and a subtype of myasthenia gravis (MG). The study, conducted in Italy, revealed the presence of muscle-specific kinase (MuSK) protein in tumor samples from patients with MuSK myasthenia gravis (MuSK-MG). The data also indicated a higher likelihood…
UCB’s injection therapy Zilbrysq (zilucoplan) has gained approval in Canada for treating adults with generalized myasthenia gravis (gMG) who are positive for antibodies targeting the acetylcholine receptor (AChR). The decision by Health Canada was supported by results from the Phase 3 RAISE trial (NCT04115293), in which the…
An under-the-skin, or subcutaneous, injectable form of efgartigimod alfa has been approved in China to treat adults with generalized myasthenia gravis (gMG) who test positive for antibodies against the acetylcholine receptor. The therapy was approved as an add-on to standard gMG treatment. This subcutaneous formulation of efgartigimod (efgartigimod…
Adolescent girls with juvenile myasthenia gravis (JMG) were more likely to have enlarged thymus glands than younger girls and adults with myasthenia gravis (MG), according to a retrospective study in France. The higher levels of female hormones during puberty may explain these results, the researchers noted, supporting the potential…
The incidence and prevalence of myasthenia gravis (MG) among the population in France are higher than reported for other European countries. That’s according to a retrospective population-based study, which also found the incidence of MG tended to increase with age and was associated with a higher risk of cancer.
Treatment with nipocalimab led to significant reductions in disease severity among people with generalized myasthenia gravis (gMG), as assessed by a drop in the MG Activities of Daily Living (MG-ADL) score, according to top-line data from a pivotal Phase 3 trial. Findings from the trial, dubbed VIVACITY-MG3…
Treatment with the investigational CAR T-cell therapy Descartes-08 led to deep and sustained reductions in disease severity among generalized myasthenia gravis (gMG) patients, according to top-line data from a Phase 2b clinical trial. The therapy, designed somewhat differently than others in its class, also avoided some of the potentially…
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