News

gMG patients can carry treatment resistant autoantibodies, study finds

People with generalized myasthenia gravis (gMG) can carry certain types of self-reactive antibodies — proteins that mistakenly target the body’s own cells and tissues — that drive the disease but are treatment resistant, according to a new study by Yale School of Medicine researchers. These self-reactive antibodies, or autoantibodies,…

Gefurulimab found to ease gMG symptoms in global Phase 3 trial

Treatment with gefurulimab, an experimental self-administered injection therapy, outperformed a placebo in easing symptoms of generalized myasthenia gravis (gMG) among people with the chronic autoimmune disease, the results of a Phase 3 clinical trial show. The trial met both its primary and secondary endpoints, or goals, with treatment…

Blinatumomab helps 2 women with resistant MG: Case report

A case report from Germany showed that two women with severe, treatment-resistant myasthenia gravis (MG) responded well to blinatumomab, suggesting the anti-cancer medication may offer a new option for hard-to-treat autoimmune diseases. “Since this first-in-human experience comprises two cases, our findings should be viewed as proof-of-concept rather than evidence…

Thymectomy surgery may cause long-term immune changes in MG

Surgery to remove the thymus gland led to a long-term reduction in levels of immune T-cells and to temporary changes in levels of proteins involved in regulating immune and inflammatory responses in people with myasthenia gravis (MG), a study shows. There were no significant effects on the levels of…

Povetacicept reduces disease activity in MG mouse model

Povetacicept, a treatment for autoimmune diseases in the pipeline of Vertex Pharmaceuticals, reduced disease activity in a study with a mouse model of myasthenia gravis (MG) by lowering the levels of disease-causing antibodies in the bloodstream. Researchers also observed that povetacicept outperformed efgartigimod — approved as Vyvgart…

Vyvgart found effective for 3 triple-seronegative gMG patients

Treatment with Vyvgart (efgartigimod) eased hard-to-treat symptoms for a trio of women with generalized myasthenia gravis (gMG) who tested negative for three antibodies commonly seen in the disease, according to a case series from China. Per the researchers, “this report describes three patients with triple-[seronegative] gMG successfully treated with efgartigimod,”…

New telitacicept deal aims to advance MG therapy outside China

Vor Bio has signed an exclusive license agreement to develop and market Remegen’s telitacicept — a B-cell-targeting candidate for the treatment of myasthenia gravis (MG) and other autoimmune diseases driven by self-reactive antibodies — outside of China, Hong Kong, Macau, and Taiwan. Telitacicept has been approved…