News

Vyvgart may be safe, effective in treatment-resistant MG: Review

People with refractory myasthenia gravis (MG) who fail to respond to several treatments may be effectively treated with Vyvgart (efgartigimod alfa-fcab), regardless of the type of self-reactive antibodies they carry. That’s according to a systematic review and meta-analysis, which showed that patients treated with Vyvgart saw their symptoms…

Registry data back Soliris, Ultomiris as safe, effective for gMG

Soliris (eculizumab) and Ultomiris (ravulizumab-cwvz) are generally safe and effective for easing symptoms of generalized myasthenia gravis (gMG) when used in everyday clinical practice. That’s according to data from the MG SPOTLIGHT Registry (NCT04202341), which was established to assess the long-term effectiveness of both therapies in…

Claseprubart shows good safety, signs of effectiveness in gMG trial

Treatment with the experimental injection therapy claseprubart (DNTH103) was well tolerated and appeared to ease symptoms of generalized myasthenia gravis (gMG) in a Phase 2 clinical trial involving people with the autoimmune neuromuscular condition. That’s according to top-line data announced by the therapy’s developer Dianthus Therapeutics. The…

Cemdisiran significantly eases disease activity in gMG adults

Cemdisiran, an under-the-skin injection therapy given every three months, significantly reduced disease activity in people with generalized myasthenia gravis (gMG) after six months of treatment. That’s according to data from the Regeneron Pharmaceuticals-sponsored Phase 3 NIMBLE study (NCT05070858), which evaluated cemdisiran as a monotherapy, as well as…

Rituximab offers long-term relief for women with MuSK-MG

Rituximab may be safe and effective in treating women with myasthenia gravis (MG) that’s driven by antibodies that target muscle-specific tyrosine kinase (MuSK), an analysis of patients at a single center in China shows. Significant symptom relief was seen by 90% of patients after a month of treatment and it…