Lindsey Shapiro, PhD,  science writer—

A rare case of myasthenia gravis (MG) that preceded the onset of autoimmune encephalitis (AE) — a type of autoimmune disease affecting the brain — was described in a recent case report. The 24-year-old man, who didn’t test positive for MG-associated antibodies, but did have two distinct types of…

Treatment with rozanolixizumab — an investigational therapy being developed by UCB for generalized myasthenia gravis (gMG) — worked in a clinical trial to ease symptom severity for a subset of patients who were positive for muscle specific kinase (MuSK) antibodies. That’s according to analyses from the Phase…

The use of Ultomiris (ravulizumab) led to stronger reductions in generalized myasthenia gravis (gMG) symptoms for people who had been living with the disease for no more than two years, new analyses from the CHAMPION MG trial indicated. “Overall, our analysis suggests that treatment of gMG with [Ultomiris]…

Ultomiris (ravulizumab) treatment led to sustained reductions in generalized myasthenia gravis (gMG) symptom severity and acute clinical worsening events for more than a year, according to new analyses from the CHAMPION MG clinical trial and its open-label extension (OLE). The analyses were presented at the Muscular Dystrophy Association’s…

Vyvgart (efgartigimod) eased symptoms of generalized myasthenia gravis (gMG) in patients regardless of their disease length, treatment history, or acetylcholine receptor (AChR) antibody status, according to two new analyses from the ADAPT clinical trial and its open-label extension, ADAPT+. These findings serve to reinforce “the efficacy of efgartigimod…

Sanofi is stopping the clinical development of tolebrutinib for treating myasthenia gravis (MG), the company announced in a recent press release. The decision was made after “careful evaluation of the emerging competitive treatment landscape in MG,” according to Sanofi, and will result in discontinuing the Phase…

MuSK-CAART, an investigational cell-based therapy being developed to treat myasthenia gravis (MG) patients with anti-MuSK antibodies, eliminated disease-driving B-cells in a mouse model of the disease, a study showed. The findings, some of which were reported previously at a scientific conference, supported Cabaletta Bio’s request for a…

Treatment with an antibody targeting the interleukin-23 (IL-23) protein reduced symptoms and eased inflammation in mouse models of myasthenia gravis (MG), a study found. Evidence suggested the antibody lowers the activation of T-helper 17 (Th17) cells — a cell family implicated in MG and other autoimmune diseases — in…

Researchers have identified clinical factors that increase the risk of a post-operative myasthenic crisis (POMC) for patients with myasthenia gravis (MG) who have surgery to remove the thymus gland. Among the risk factors listed are more severe MG with respiratory muscle involvement, pre-operative use of a high dose of pyridostigmine…

Shedding of the muscle-specific tyrosine kinase (MuSK) protein from the surface of muscle cells into the bloodstream could be the reason why anti-MuSK antibodies drive myasthenia gravis (MG) in some cases, according to a study. The protein was found in the blood of healthy mice and people, and was…