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New approved MG treatment for gMG – Vyvgart Hytrulo
The FDA has approved Argenx’s subcutaneous injection (given in the fatty tissue just under the skin) formulation of efgartigimod, called Vyvgart Hytrulo, to treat adults with generalized myasthenia gravis, https://myastheniagravisnews.com/news/fda-approves-subcutaneous-efgartigimod-vyvgart-hytrulo-gmg/.
Efgartigimod alfa is the active agent in Vyvgart and a recombinant human hyaluronidase PH20 enzyme. That enzyme is crucial in the under-the-skin injection delivery, which takes less than two minutes to be administered.
In comparison, the into-the-vein or intravenous therapy takes about one hour.
This is very exciting! Is anyone eager to discuss this treatment with their doctor to see if you are a candidate?
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6 Replies
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I was very excited about the idea of a subQ Vyvgart, But I’m not as comfortable with the additional drugs yet. I have MCAS and Chemical allergies so I will watch for a while. I had hoped to get the injection at a local Neurologist, saving 3 hours of driving and 2 hours in the infusion center. Also sparing my veins.
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Anyone here of octagam? I’m mg negative and my first infusion.
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Thanks Jodi
I will contact my doctor to find out.
Please keep me posted
Thanks again
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My Neurologist is putting in the order right now. I did ask my Vyvgart Hytrulo case officer to have it done with my own Doctor(15 mins away, instead of 45 mins way at the infusion center) or indeed have it done at my own home. No go with my own Doctor(no doubt a money thing) and would have to get insurance to approve it being administered at home.
The whole point of this is the fact that they always have a hard time sticking me, so a simple injection is wonderful not to mention the time saved. I gave my wife Forteo injections for one year, and you would have thought they could have got this organized by now, and yet It’s still all about who gets a slice of the green stuff in the end.
Regardless, this will be my third series of Vyvgart and when I start, and finish will let others know how it went, but more importantly, how I did and the hopeful and continued improvement with my health would be nice.🥂
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Vyvgart infusions didn’t work for me for very long. The 3-4 weeks off is the killer. Is it just me or do another people have a problem with the time off as well. And insurance won’t cover weekly no time off.
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I’ve had two cycles of Vyvgard via IV. My results have been very good and have started reducing Prednisone. My next cycle will be Hytrulo.
I’ve gone from 8 hours of IVIG given over two consecutive days, to 90 seconds/week for each of 4 consecutive weeks. Amazing.
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