Sanofi has decided to pause recruitment globally in its Phase 3 clinical trials of tolebrutinib, an experimental BTK inhibitor, based on recommendations from the independent data monitoring committee (iDMC) overseeing the trials. The company has several ongoing studies investigating tolebrutinib’s effectiveness and safety, including one testing the investigational therapy…
The Moderna COVID-19 vaccine was safe and did not particularly worsen clinical symptoms in people with myasthenia gravis (MG), a Spanish study reported. Patients developed a robust immune response after receiving the two recommended doses, despite being on immunosuppressive therapies. Additionally, no participant developed COVID-19 throughout the study. The…
COVID-19 infection prolongs the length of hospital stay by nearly twofold for patients with myasthenia gravis (MG), according to a U.S. database study. The study, “Impact of COVID-19 infection among myasthenia gravis patients- a Cerner Real-World Data study,” was published in the journal BMC Neurology. In MG, the…
People with myasthenia gravis (MG) have an increased risk of developing systemic lupus erythematosus or SLE, another type of autoimmune disorder, according to recent study findings that suggest “a real association between these two diseases.” Especially at risk are African American women, those who had surgery to remove…
An extremely rare case of myasthenia gravis (MG) associated with paroxysmal nocturnal hemoglobinuria (PNH) and aplastic anemia (AA), two bone marrow failure conditions in which the immune system mistakenly attacks developing red blood cells, was reported recently. The report, “Myasthenia gravis and paroxysmal nocturnal hemoglobinuria after thymectomy: A…
Bladder problems like urinary incontinence, urgency, and nocturia — waking up frequently to urinate — are common in people with myasthenia gravis (MG), particularly those with late-onset disease, a study found. Late-onset MG, or LOMG, is defined as disease symptoms that begin after age 50, while symptoms in early-onset…
Patients who start experiencing symptoms of myasthenia gravis (MG) after age 65 have an overall good prognosis and response to immunosuppressive treatments, according to a recent Canadian study. In addition, the presence of other medical conditions, or comorbidities, had no effect on the severity of MG symptoms or on…
People with generalized myasthenia gravis (MG) who have other diseases, or comorbidities, have a worse prognosis and are less likely to go into remission after thymus removal than those without other medical conditions. Those were the findings of a recent study that followed patients for about nine years after…
Poor lung function and disease management, along with previous long-term use of corticosteroids, older age, and the presence of cancer are the most significant predictors of severe COVID-19 among people with myasthenia gravis (MG), according to a recent study. The findings also indicated that the odds of death…
People with myasthenia gravis (MG) are not at a higher risk of developing atrial fibrillation, a potentially serious heart condition that causes the heart to beat irregularly and often faster than normal, a study from Taiwan reports. The study, “Risk of subsequent atrial fibrillation in patients with myasthenia…
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