Three microRNAs (miRNAs) — small strands of RNA that regulate protein production — in blood samples accurately identified people with early-onset ocular myasthenia gravis (OMG) and distinguished them from early-onset generalized myasthenia gravis (gMG) patients and healthy people in a recent study. “These results suggested that the three…
Among caregivers of people with myasthenia gravis (MG) living in Northwest China, care burden rises with disease severity and the degree of the patient’s depression, a study reported. According to its researchers, this is primarily driven by patients’ inability to participate more fully in household chores, and the increasing…
Kyverna Therapeutics’ investigational cell therapy KYV-101 safely and effectively improved muscle strength and reduced fatigue in a woman with severe, hard-to-treat generalized myasthenia gravis (gMG), according to a case report. The patient was treated based on an individual case evaluation and outside of a clinical trial. “This groundbreaking…
Recipharm is partnering with Ahead Therapeutics to develop a new type of therapy to reestablish immune tolerance and prevent the self-reactive immune attacks that cause myasthenia gravis (MG). “Together with our partner, we are determined to help them turn hope into reality for people living with myasthenia…
A thymectomy, or surgical removal of the thymus gland, was effective for children and adolescents with myasthenia gravis (MG), as indicated by lower medication use and healthcare utilization after surgery, a study reports. Demographic characteristics like age, sex, ethnicity, insurance payer type, residential region, and the surgical approach…
The National Medical Products Administration (NMPA) of China has agreed to consider approving batoclimab (HBM9161) for treating generalized myasthenia gravis (gMG). Submitted as a biologics license application (BLA), the request is supported by positive top-line data from a Phase 3 clinical trial (NCT05039190) from China. The trial…
Immunosuppressive therapies, administered with or without acetylcholinesterase inhibitors, helped ease symptoms of ocular myasthenia gravis (MG), according to an analysis of medical records from several hospitals in Japan. Although treatment was associated with favorable outcomes, some symptoms persisted in more than half the treated patients. Still, immunotherapy, including corticosteroids,…
Repetitive nerve stimulation (RNS), a standard tool used to diagnose myasthenia gravis (MG), was unable to predict disease severity over the long term, or other MG outcomes, among people with the neuromuscular condition, a study found. While there was a correlation between RNS results and disease severity at symptom…
Patient dosing has begun in the first placebo-controlled clinical trial evaluating Cartesian Therapeutics’ Descartes-08, an investigational CAR T-cell therapy for people with generalized myasthenia gravis (gMG). The Phase 2b randomized controlled trial (RCT), to include up to 30 adults with gMG, follows a crossover design, in which participants…
Adults with myasthenia gravis (MG) have elevated levels of protein fragments released from T follicular helper (Tfh) cells — an immune cell type involved in the development of autoimmune conditions — in their bloodstream, a study reported. According to researchers, these results suggest that molecules associated with Tfh cells…
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