The National Medical Products Administration (NMPA) of China has agreed to consider approving batoclimab (HBM9161) for treating generalized myasthenia gravis (gMG). Submitted as a biologics license application (BLA), the request is supported by positive top-line data from a Phase 3 clinical trial (NCT05039190) from China. The trial…
Immunosuppressive therapies, administered with or without acetylcholinesterase inhibitors, helped ease symptoms of ocular myasthenia gravis (MG), according to an analysis of medical records from several hospitals in Japan. Although treatment was associated with favorable outcomes, some symptoms persisted in more than half the treated patients. Still, immunotherapy, including corticosteroids,…
Repetitive nerve stimulation (RNS), a standard tool used to diagnose myasthenia gravis (MG), was unable to predict disease severity over the long term, or other MG outcomes, among people with the neuromuscular condition, a study found. While there was a correlation between RNS results and disease severity at symptom…
Patient dosing has begun in the first placebo-controlled clinical trial evaluating Cartesian Therapeutics’ Descartes-08, an investigational CAR T-cell therapy for people with generalized myasthenia gravis (gMG). The Phase 2b randomized controlled trial (RCT), to include up to 30 adults with gMG, follows a crossover design, in which participants…
Adults with myasthenia gravis (MG) have elevated levels of protein fragments released from T follicular helper (Tfh) cells — an immune cell type involved in the development of autoimmune conditions — in their bloodstream, a study reported. According to researchers, these results suggest that molecules associated with Tfh cells…
The Comirnaty mRNA COVID-19 vaccine was safe and well tolerated in people with myasthenia gravis (MG), a study confirmed. Worsening of MG symptoms after the third vaccine dose occurred in eight of the 113 study participants (7.1%) who were all successfully treated with standard immunoglobulins (IVIG). While…
The onset of myasthenia gravis (MG) occurs at a significantly younger age in people who smoke, a study has found. Women who smoked at MG onset, or within 10 years before its onset, were significantly younger at disease onset than men. Yet, no sex differences were seen among those…
Subcutaneous immunoglobulin therapy (SCIg) — given by under-the-skin injection — was well-tolerated and effective in the management of adults with myasthenia gravis (MG), a small study has found. Although the therapy is approved for other diseases related to immune system deficiency, and is currently under investigation as an…
Two doses of the COVID-19 vaccine did not worsen symptoms in 200 people with myasthenia gravis (MG), with mostly injection site-related side-effects reported, matching those seen in the general population, a study reported. These findings contrast with those of a recent study suggesting that, in very rare cases,…
An under-the-skin injection formulation of efgartigimod is as effective as the therapy’s infusion version, sold as Vyvgart (efgartigimod alfa-fcab), at lowering immunoglobulin G antibody levels in people with generalized myasthenia gravis (gMG), according to top-line data from the ADAPT-SC trial. Based on these findings, Argenx, the therapy’s developer, plans…
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