Steve Bryson, PhD, science writer —

Both Soliris (eculizumab) and Vyvgart (efgartigimod alfa-fcab) rapidly eased disease severity among adults with generalized myasthenia gravis (gMG), according to a real-world study that compared the two therapies. Soliris outperformed Vyvgart in its ability to reduce gMG severity and corticosteroid dose over a year of treatment, however.

Using a combination of two standardized assessment tools may be better than the classification process now in place in predicting the outcomes of people with a thymoma, or thymus tumor, associated with myasthenia gravis (MG), a new study suggests. The newly proposed system, from researchers in China, would classify…

The anti-malaria drug dihydroartemisinin, known simply as DHA, showed promise in a rat model of myasthenia gravis (MG) as a potential treatment for the autoimmune disease, a new study reports. In addition to alleviating many MG-related symptoms, DHA inhibited pro-inflammatory T-cells while boosting immune-suppressing T-regulatory cells. Treatment with the…

People with myasthenia gravis (MG) who have more active disease are at a higher risk of having an exacerbation, or a sudden worsening of symptoms, a new study from Germany has found. Even after appropriate treatment for an exacerbation, this group of MG patients remained clinically more impaired, the…

Nearly six months of treatment with RemeGen’s telitacicept (RC18) lessened disease activity in adults with generalized myasthenia gravis (gMG) who are positive for antibodies targeting the acetylcholine receptor, according to data from a Phase 2 clinical trial in China. “Telitacicept demonstrated safety [and] good tolerability and reduced clinical…

Patients, especially women, experience a high degree of side effects from myasthenia gravis (MG) treatment, according to a U.K. survey examining real-world use of the medications. As steroid-sparing agents, mycophenolate mofetil (sold as CellCept) and methotrexate (sold as Trexall, among others) were less likely to be discontinued…

A woman with hard-to-treat generalized myasthenia gravis (gMG) who was seronegative, or tested negative for disease-driving self-directed antibodies, was successfully treated with off-label Vyvgart (efgartigimod alfa-fcab), as reported in a case study from Italy. According to researchers, this case provides evidence that limiting Vyvgart to MG patients with…

The initial treatment benefits of Soliris (eculizumab) were maintained after people with generalized myasthenia gravis (gMG) switched over to Ultomiris (ravulizumab-cwvz), a small real-world study confirmed. Most patients who completed a survey almost six months after switching said they preferred Ultomiris due to treatment convenience, lower frequency…

The U.S. Food and Drug Administration (FDA) has given the green light to Iaso Bio to start clinical testing of its BCMA CAR T-cell therapy equecabtagene autoleucel, known as Eque-cel for short, in people with generalized myasthenia gravis (gMG) who live in the U.S. Clearance of the company’s request,…

A single dose of IASO Bio’s experimental BCMA CAR T-cell therapy equecabtagene autoleucel (CT103A) led to sustained physical function gains in two people with hard-to-treat myasthenia gravis (MG), a recent study suggests. “In our study, it is gratifying to see that BCMA CAR-T cell therapy can prevent MG…