Do myasthenia gravis symptoms get worse?

In general, myasthenia gravis symptoms progress over the long term, typically reaching their worst about three years after disease onset. MG symptoms also fluctuate throughout the day, getting worse during periods of activity and easing with rest. Certain disease triggers, such as stress, infection, hormonal changes, and some medications also may worsen symptoms and cause a disease flare or a myasthenic crisis.