News

A new study comparing outcomes of two different strategies for treating generalized myasthenia gravis (gMG) found that both the approved med Vyvgart (efgartigimod alfa) and a blood-cleaning procedure called double-filtration plasmapheresis (DFPP) were generally equally effective in easing symptoms. Both treatments significantly reduced disease-causing antibodies and improved daily…

A small clinical trial found early signs that Cabaletta Bio’s experimental CAR T-cell therapy rese-cel (resecabtagene autoleucel) may safely ease symptoms for adults with generalized myasthenia gravis (gMG). That’s according to data from the U.S.-based Phase 1/2 RESET-MG trial (NCT06359041), in which participants with different types of…

More than 90% of people with generalized myasthenia gravis (gMG) treated with telitacicept for about a year achieved deep reductions in symptom severity, with more than 40% showing minimal symptoms that had little to no impact on daily life. That’s according to new data from a China-based Phase…

A second round of Descartes-08, Cartesian Therapeutics’ experimental CAR T-cell therapy, may allow some people with generalized myasthenia gravis (gMG) to sustain clinically meaningful symptom reduction, according to data from a clinical trial. James F. Howard Jr., MD, a trial investigator and University of North Carolina School of…

For many people living with rare neuromuscular diseases, the most meaningful part of a recent Chicago gathering was not just the medical updates — it was finding a community that understood their daily struggles. The realization that they were not alone set the tone for MDA Engage: Chicago, a…

Regeneron Pharmaceuticals’ investigational therapy cemdisiran significantly reduced hospitalization rates among people with generalized myasthenia gravis (gMG) in a global clinical trial. The data from the Phase 3 NIMBLE study (NCT05070858) were presented by trial investigator Ali Habib, MD, a neurologist at the University of California, Irvine, at…

A single dose of Kyverna Therapeutics’ experimental CAR T-cell therapy mivocabtagene autoleucel (miv-cel) led to reductions in symptom severity among people with difficult-to-treat generalized myasthenia gravis (gMG) that have been sustained for up to 1.5 years. Importantly, most participants reached a state where their gMG symptoms have…

People living with myasthenia gravis (MG) have more treatment options today than ever before, and emerging approaches like CAR T-cell therapy could soon add another powerful tool, a neurologist told patients and caregivers at a recent educational event. Even with a growing list of therapies, effective care still…

Myasthenia gravis (MG) patients who didn’t have thymus tumors saw reductions in disease severity and medication use two years after undergoing a type of minimally invasive thymectomy (surgery to remove the thymus gland), a study showed. Most of the 33…

An experimental cell therapy designed to selectively eliminate immune cells that produce the most common disease-driving antibodies in myasthenia gravis (MG) showed promise in laboratory and mouse models. The treatment involves engineering immune T-cells to selectively kill B-cells producing self-reactive antibodies (autoantibodies) against the…