José Lopes, PhD

José holds a BSc in Biochemistry and a PhD in Neuroscience from the University of Porto, in Portugal, and did post-docs in the U.S. and Canada (Weill Cornell Medicine and Western University, respectively) while still in academia. He joined Bionews in 2017 as a science writer and became a managing science editor in 2019. At Bionews, he has been able to cover the latest news related to multiple disease communities, while also doing interviews and covering several meetings. He is an author of 20 peer-reviewed papers and two book chapters. Topics of his research included the brain mechanisms implicated in Alzheimer’s disease, hypertension, and menopause. He also is a professor at the School of Health, Polytechnic of Porto.

Education

• PhD in Neuroscience, Faculty of Medicine of Univerity of Porto, Portugal (2011)
• BSc in Biochemistry, Faculty of Sciences of University of Porto, Portugal (2004)

Professional Organizations and Affiliations

• Invited adjunct professor at ESS, Polytechnic of Porto, Portugal
• Integrated researcher at RISE-Health, Center for Translational Health and Medical Biotechnology Research (TBIO), ESS, Polytechnic of Porto, Portugal
• Integrated researcher at RISE-Health, Center for Translational Health and Medical Biotechnology Research (TBIO), ESS, Polytechnic of Porto, Portugal

Published Works

• Sommer G, Rodríguez López C, Hirschkorn A, Calimano G, Marques-Lopes J, Milner TA, Glass MJ. Estrogen Receptor Beta Agonist Influences Presynaptic NMDA Receptor Distribution in the Paraventricular Hypothalamic Nucleus Following Hypertension in a Mouse Model of Perimenopause. Biology (Basel). 2024 Oct 12;13(10):819. doi: 10.3390/biology13100819
• Milner TA, Chen RX, Welington D, Rubin BR, Contoreggi NH, Johnson MA, Mazid S, Marques-Lopes J, Marongiu R, Glass MJ. Angiotensin II differentially affects hippocampal glial inflammatory markers in young adult male and female mice. Learn Mem. 2022 Sep 6;29(9):265-273. doi: 10.1101/lm.053507.121
• Woods C, Marques-Lopes J, Contoreggi NH, Milner TA, Pickel VM, Wang G, Glass MJ. Tumor Necrosis Factor α Receptor Type 1 Activation in the Hypothalamic Paraventricular Nucleus Contributes to Glutamate Signaling and Angiotensin II-Dependent Hypertension. J Neurosci. 2021 Feb 10;41(6):1349-1362. doi: 10.1523/JNEUROSCI.2360-19.2020
• Lackie RE, Marques-Lopes J, Ostapchenko VG, Good S, Choy WY, van Oosten-Hawle P, Pasternak SH, Prado VF, Prado MAM. Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2020 Aug 21;8(1):143. doi: 10.1186/s40478-020-01013-5
• Rubin BR, Milner TA, Pickel VM, Coleman CG, Marques-Lopes J, Van Kempen TA, Kazim SF, McEwen BS, Gray JD, Pereira AC. Sex and age differentially affect GABAergic neurons in the mouse prefrontal cortex and hippocampus following chronic intermittent hypoxia. Exp Neurol. 2020 Mar;325:113075. doi: 10.1016/j.expneurol.2019.113075
• Ovalles AC, Contoreggi NH, Marques-Lopes J, Van Kempen TA, Iadecola C, Waters EM, Glass MJ, Milner TA. Plasma Membrane Affiliated AMPA GluA1 in Estrogen Receptor β-containing Paraventricular Hypothalamic Neurons Increases Following Hypertension in a Mouse Model of Post-menopause. Neuroscience. 2019 Dec 15;423:192-205. doi: 10.1016/j.neuroscience.2019.09.026
• Lackie RE, Maciejewski A, Ostapchenko VG, Marques-Lopes J, Choy WY, Duennwald ML, Prado VF, Prado MAM. The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases. Front Neurosci. 2017 May 16;11:254. doi: 10.3389/fnins.2017.00254
• Marques-Lopes J, Tesfaye E, Israilov S, Van Kempen TA, Wang G, Glass MJ, Pickel VM, Iadecola C, Waters EM, Milner TA. Redistribution of NMDA Receptors in Estrogen-Receptor-β-Containing Paraventricular Hypothalamic Neurons following Slow-Pressor Angiotensin II Hypertension in Female Mice with Accelerated Ovarian Failure. Neuroendocrinology. 2017;104(3):239-256. doi: 10.1159/000446073
• Van Kempen TA, Narayan A, Waters EM, Marques-Lopes J, Iadecola C, Glass MJ, Pickel VM, Milner TA. Alterations in the subcellular distribution of NADPH oxidase p47(phox) in hypothalamic paraventricular neurons following slow-pressor angiotensin II hypertension in female mice with accelerated ovarian failure. J Comp Neurol. 2016 Aug 1;524(11):2251-65. doi: 10.1002/cne.23944
• Van Kempen TA, Dodos M, Woods C, Marques-Lopes J, Justice NJ, Iadecola C, Pickel VM, Glass MJ, Milner TA. Sex differences in NMDA GluN1 plasticity in rostral ventrolateral medulla neurons containing corticotropin-releasing factor type 1 receptor following slow-pressor angiotensin II hypertension. Neuroscience. 2015 Oct 29;307:83-97. doi: 10.1016/j.neuroscience.2015.08.029
• Marques-Lopes J, Lynch MK, Van Kempen TA, Waters EM, Wang G, Iadecola C, Pickel VM, Milner TA. Female protection from slow-pressor effects of angiotensin II involves prevention of ROS production independent of NMDA receptor trafficking in hypothalamic neurons expressing angiotensin 1A receptors. Synapse. 2015 Mar;69(3):148-65. doi: 10.1002/syn.21800
• Marques-Lopes J, Van Kempen T, Waters EM, Pickel VM, Iadecola C, Milner TA. Slow-pressor angiotensin II hypertension and concomitant dendritic NMDA receptor trafficking in estrogen receptor β-containing neurons of the mouse hypothalamic paraventricular nucleus are sex and age dependent. J Comp Neurol. 2014 Sep 1;522(13):3075-90. doi: 10.1002/cne.23569
• Wang G, Coleman CG, Chan J, Faraco G, Marques-Lopes J, Milner TA, Guruju MR, Anrather J, Davisson RL, Iadecola C, Pickel VM. Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons. Am J Physiol Regul Integr Comp Physiol. 2013 Jun 15;304(12):R1096-106. doi: 10.1152/ajpregu.00367.2012
• Coleman CG, Wang G, Faraco G, Marques Lopes J, Waters EM, Milner TA, Iadecola C, Pickel VM. Membrane trafficking of NADPH oxidase p47(phox) in paraventricular hypothalamic neurons parallels local free radical production in angiotensin II slow-pressor hypertension. J Neurosci. 2013 Mar 6;33(10):4308-16. doi: 10.1523/JNEUROSCI.3061-12.2013
• Gonzalez AD, Wang G, Waters EM, Gonzales KL, Speth RC, Van Kempen TA, Marques-Lopes J, Young CN, Butler SD, Davisson RL, Iadecola C, Pickel VM, Pierce JP, Milner TA. Distribution of angiotensin type 1a receptor-containing cells in the brains of bacterial artificial chromosome transgenic mice. Neuroscience. 2012 Dec 13;226:489-509. doi: 10.1016/j.neuroscience.2012.08.039
• Marques-Lopes J, Martins I, Pinho D, Morato M, Wilson SP, Albino-Teixeira A, Tavares I. Decrease in the expression of N-methyl-D-aspartate receptors in the nucleus tractus solitarii induces antinociception and increases blood pressure. J Neurosci Res. 2012 Feb;90(2):356-66. doi: 10.1002/jnr.22760
• Pinho D, Morato M, Couto MR, Marques-Lopes J, Tavares I, Albino-Teixeira A. Does chronic pain alter the normal interaction between cardiovascular and pain regulatory systems? Pain modulation in the hypertensive-monoarthritic rat. J Pain. 2011 Feb;12(2):194-204. doi: 10.1016/j.jpain.2010.06.009. Epub 2010 Aug 23. Erratum in: J Pain. 2016 Apr;17(4):511. doi: 10.1016/j.jpain.2015.12.011
• Marques-Lopes J, Pinho D, Albino-Teixeira A, Tavares I. The hyperalgesic effects induced by the injection of angiotensin II into the caudal ventrolateral medulla are mediated by the pontine A5 noradrenergic cell group. Brain Res. 2010 Apr 14;1325:41-52. doi: 10.1016/j.brainres.2010.02.043
• Marques-Lopes J, Pinto M, Pinho D, Morato M, Patinha D, Albino-Teixeira A, Tavares I. Microinjection of angiotensin II in the caudal ventrolateral medulla induces hyperalgesia. Neuroscience. 2009 Feb 18;158(4):1301-10. doi: 10.1016/j.neuroscience.2008.11.044
• Sousa T, Pinho D, Morato M, Marques-Lopes J, Fernandes E, Afonso J, Oliveira S, Carvalho F, Albino-Teixeira A. Role of superoxide and hydrogen peroxide in hypertension induced by an antagonist of adenosine receptors. Eur J Pharmacol. 2008 Jul 7;588(2-3):267-76. doi: 10.1016/j.ejphar.2008.04.044
• Book chapter: Marques-Lopes J, Van Kempen TA, Milner TA. Rodent Models of Ovarian Failure. In Conn’s Handbook of Models for Human Aging, ed. 2018, J. L. P. M. Conn 831 844. Elsevier Inc.
• Book chapter: Van Kempen TA, Marques-Lopes J, Glass MJ, Milner TA Sex differences in neural regulation of hypertension. In Hypertension and the Brain as an End-Organ Target, ed. H. Girouard 2016, 195-221. Springer International Publishing
• Young Investigator Award finalist, Gordon Research Conference on Angiotensin – Molecular Basis For Action, Dysfunction And New Therapeutic Approaches, Feb 2010. Ventura, California

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