People with refractory myasthenia gravis (MG) who fail to respond to several treatments may be effectively treated with Vyvgart (efgartigimod alfa-fcab), regardless of the type of self-reactive antibodies they carry. That’s according to a systematic review and meta-analysis, which showed that patients treated with Vyvgart saw their symptoms…
Certain inflammatory molecules known as cytokines may play a role in a person’s risk of developing myasthenia gravis (MG), according to a recent genetic study. The research suggests some of these immune-system signaling molecules could increase the risk of the autoimmune disease, while others might offer protection. The findings, which…
Surgery to remove the thymus gland led to a long-term reduction in levels of immune T-cells and to temporary changes in levels of proteins involved in regulating immune and inflammatory responses in people with myasthenia gravis (MG), a study shows. There were no significant effects on the levels of…
A higher body mass index (BMI), a measure of body fat based on height and weight, is associated with an increased risk of progression from ocular to generalized myasthenia gravis (MG), according to a study in China. Ocular MG is a type of MG in which muscle weakness…
The U.S. Food and Drug Administration (FDA) has cleared the launch of a Phase 2 clinical trial testing IM-101, ImmunAbs’ investigational therapy for myasthenia gravis (MG). The multicenter, placebo-controlled trial is expected to enroll up to 90 people with MG who will receive IM-101 or a placebo once monthly.
The first patient has joined a Phase 3 clinical trial assessing the safety and efficacy of Descartes-08, an investigational cell therapy for myasthenia gravis (MG) being developed by Cartesian Therapeutics. Called AURORA (NCT06799247), the trial is expected to enroll 100 adults with generalized MG (gMG), a more…
People with generalized myasthenia gravis (gMG) who were misdiagnosed at least once and who have certain disease symptoms are more likely to see an increase in disease severity, according to a recent study. Ocular symptoms and/or muscle aches after physical activity were significantly associated with a higher risk of…
Rituximab may be safe and effective in treating young children with myasthenia gravis (MG) driven by antibodies that target muscle-specific tyrosine kinase (MuSK), according to a report detailing the case of a 4-year-old girl. The girl was one of the youngest MG patients to have received rituximab, according…
Treatment with Remegen’s telitacicept over nearly six months safely reduced disease severity in adults with generalized myasthenia gravis (gMG) and helped ease these patients’ symptoms. That’s according to new data from a Phase 3 clinical trial (NCT05737160) that was presented in a late-breaking session at this year’s…
Myasthenia gravis (MG) is associated with a high personal and societal economic burden, due to work engagement and income difficulties, physician visits, hospitalizations, and medications. That’s according to a new study from Germany that analyzed responses from patient surveys on personal burden, as well as data from a claims…
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