The clinical-stage biotech company argenx is planning to start a pivotal Phase 3 trial of efgartigimod (ARGX-113) for generalized myasthenia gravis (gMG) before the end of the year. The company announced it has received guidance from the U.S. Food and Drug Administration following an End-of-Phase 2 meeting. The Phase…
For the first time, a case of myasthenia gravis in combination with damaged bone marrow and an inflammatory muscle disease was reported in a patient. This rare case was described in the journal Case Reports in Neurology, in the study “Autologous Bone Marrow Transplantation for Polymyositis…
As President Trump signed the recently passed Right to Try legislation into law in a White House ceremony, Jordan McLinn of Indianapolis tried twice to embrace him. The third time, 9-year-old Jordan finally got the hug he wanted — as well as a kiss on the forehead. The video of…
Between 30 percent and 50 percent of all thymoma patients – people treated for a tumor in the thymus gland – go on to develop myasthenia gravis, and as a case study reports, this disease’s appearance can sometimes be associated with a return of the cancer. The study detailed an…
Finding treatments and potential cures for rare diseases is crucial, but so is the quality of patients’ lives — a rather nebulous term that means different things to different people. “Recently, there’s been much more of a focus on Quality of Life (QoL) issues, real-world evidence and patient-reported outcomes,” said…
Treatment with Rituxan (rituximab) provided sustained clinical improvement, increased muscle strength, and extended the time before disease worsening in myasthenia gravis, according to researchers. It also allows myasthenia gravis (MG) patients who are resistant to conventional treatment to reduce their dose…
Concentric needle-jitter is more accurate in diagnosing myasthenia gravis (MG) than repetitive nerve stimulation or acetylcholine receptor antibody positivity, a study reports. The study, “Repetitive nerve stimulation and jitter measurement with disposable concentric needle electrode in newly diagnosed myasthenia gravis patients,” was published in the journal…
Careful patient assessment and planning prior to surgery was needed to successfully remove a tumor from the thymus of a myasthenia gravis patient with a recent history of adult respiratory distress syndrome, researchers in Greece reported. Their case study, “Thymectomy in a patient with thymoma -related myasthenia Gravis and recent…
Surgeons in China have developed a new way of removing the thymus — a procedure called a thymectomy — in myasthenia gravis patients that may be both easier on the doctors operating and likely to improve post-operative outcomes in patients. The method was described and validated in the study, “…
Patients with myasthenia gravis (MG) have higher levels of a chemical modification — known as DNA methylation — on the CTLA-4 gene, which is linked to higher levels of autoantibodies and inflammatory molecules, according to researchers. The study, “CTLA-4 methylation regulates the pathogenesis of myasthenia gravis and the…
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