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Negative/normal repetitive nerve stimulation and single fiber electromyography tests
Did your repetitive nerve stimulation (RNS) test and single fiber electromyography (EMG) results return negative or normal? These tests often cause confusion regarding Myasthenia gravis testing, especially for those attempting to confirm a seronegative MG diagnosis.
Repetitive nerve stimulation (RNS) test assesses the nerve cell’s capacity to signal to a muscle. An electrode placed on the skin repeatedly stimulates nerves near specific muscles.
Single-fiber electromyography (EMG) is one of the more sensitive MG diagnostic tests, which measures muscle fibers’ response to stimulation.
A wire electrode is inserted through the skin into a muscle and electrically stimulates a single muscle fiber.
With MG, muscle fibers are less responsive to repeated electrical stimulation than those without the disease. Additionally, when a nerve’s ability to signal to a muscle reduces over numerous rounds, it may suggest MG.
However, you may still have Myasthenia gravis, even with negative RNS and single-fiber EMG results. “In seronegative myasthenia gravis repetitive nerve stimulation and single-fiber EMG have a crucial diagnostic value but they may be negative, particularly in repetitive nerve stimulation studies”.
Did you have RNS and single-fiber EMG results that suggested against you having Myasthenia gravis? Were you eventually able to receive a diagnosis? If you got a confirmed MG diagnosis, which tests, imaging, or blood tests ultimately gave you answers?
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